Commercial air service into the Santa Fe airport exists but is distinctly limited. If entering New Mexico via the larger Albuquerque airport, simply rent a car and drive, as there is currently no commuter air service connecting these two airports. The flights directly into Santa Fe all originate instead in Denver.

By rail

The major Amtrak route across the Southwest approaches but does not enter Santa Fe. The nearest Amtrak station is at Lamy about 15 miles south of town on US Highway 285.

By car

Santa Fe lies along Interstate 25, which skirts the city. Be wary of weather conditions if coming to Santa Fe on this road. Santa Fe is nearly 1500' (half a kilometer) above Albuquerque, and on I-25, most of the elevation change is on a single long, steep hill known as "La Bajada." La Bajada hill is hairy to drive during winter snowstorms and is frequently closed for periods of several hours. North of town, I-25 goes over a moderate pass along the southern end of the Sangre de Cristo Mountains before heading out into the plains; this too can be closed during blizzards, although La Bajada is the main problem. If conditions are good and you're not in a hurry, consider using back roads as an alternative to I-25 if coming from Albuquerque. State road 14 passes along the east side of the Sandia Mountains and through the quaint little towns of Madrid and Cerrillos before joining the interstate just south of Santa Fe.